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creation of the - barrier, which is a semipermeable structure that protects the brain from potentially toxic chemicals circulating in the blood, is an important function of glia.

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Creation of the blood brain barrier, which is a semipermeable structure that protects the brain from potentially toxic chemicals circulating in the blood, is an important function of glia.

The brain is protected from poisonous substances in the blood by the blood-brain barrier (BBB), which is a specialized system of brain microvascular endothelial cells (BMVEC). It also provides nutrition to brain tissues and filters dangerous substances out of the brain and back into the bloodstream. BMVEC and other elements of the neurovascular unit, including as astrocytes, pericytes, neurons, and basement membrane, work closely together to ensure that the central nervous system (CNS) is functioning properly.

The BMVEC's luminal and abluminal membrane surfaces are functionally polarized. The BBB limits the transfer of therapeutic medicines into the CNS because of its constrained permeability. The pathogenesis of many CNS diseases is heavily influenced by BBB disruption or changes in transport networks. Such BBB disruption is frequently mediated by pro-inflammatory chemicals and specific disease-associated proteins. The regulation of the BBB structural and functional integrity emerges from shared intracellular pathways, despite the underlying reasons of BBB failure appearing to be different. The development of treatments to enhance BBB function in health and disease will be made possible by a better knowledge of tight junction control and factors affecting transport networks.

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